Identification of octadeca-9,11-dienoic acid and its significance in the diagnosis of cervical intraepithelial neoplasia
| Autor: | D.M. Parham, P. E. Ross, I.D. Duncan, A.J. Robertson, F.D. Gunstone |
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| Rok vydání: | 1989 |
| Předmět: |
Linoleic acid
Clinical Biochemistry Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Biochemistry High-performance liquid chromatography chemistry.chemical_compound Isomerism Molar ratio medicine Humans Linoleic Acids Conjugated Cervix Chromatography High Pressure Liquid Vaginal Smears Chromatography Autoxidation Chemistry Erythrocyte Membrane Biochemistry (medical) General Medicine medicine.disease medicine.anatomical_structure Linoleic Acids Carcinoma Squamous Cell Female Gas chromatography Quantitative analysis (chemistry) |
| Zdroj: | Clinica Chimica Acta. 182:289-293 |
| ISSN: | 0009-8981 |
| Popis: | In 1987 it was claimed using high performance liquid chromatography (HPLC) that the molar ratio of octadeca-9, 11-dienoic acid to its parent linoleic acid (18:2 (9, 12)) was raised in malignant and premalignant conditions of the cervix. In this study based on a gas Chromatographic procedure which prevents autoxidation and avoids the detection limitations of HPLC, we have shown that assay of these fatty acids has no role to play in the assessment of cervical neoplasia. |
| Databáze: | OpenAIRE |
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