Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors
| Autor: | Eva Češková, Jan Šimůnek, David Hampel, Lenka Sušilová, Aleš Sušil |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Hospitalized patients medicine.medical_treatment Weight Gain Body Mass Index 03 medical and health sciences Young Adult 0302 clinical medicine Medicine Humans Antipsychotic Psychiatry Retrospective Studies 2. Zero hunger Sex Characteristics business.industry Retrospective cohort study medicine.disease 3. Good health 030227 psychiatry Hospitalization Psychiatry and Mental health Schizophrenia Female business Body mass index 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | International journal of psychiatry in clinical practice. 21(2) |
| ISSN: | 1471-1788 |
| Popis: | To investigate the differences in body mass index (BMI) changes between men and women during hospitalization.The retrospective study monitored demographic and clinical data of 462 schizophrenic patients hospitalized 737 times between 2006 and 2011. BMI analysis was performed on patients on antipsychotic medication hospitalized longer than four days.Patients with an initial BMI 25 gained more weight than patients with a BMI 25 (3.94% vs. 0.23%, men 4.02% vs. 0.69%, women 3.79% vs. -0.52%, always p 0.001). Greater BMI gains were reported during the first hospitalization than during subsequent ones (3.94% vs. 1.66%, men 3.97% vs. 1.98%, women 3.88% vs. 1.18%, always p 0.001). The comparison between men and women showed a higher increase in BMI in men 2.36% vs. 1.54%, p = 0.022. Men also gained significantly more weight than women on polytherapy (+2.55% vs. +1.37%) and during subsequent hospitalizations (1.98% vs. 1.18%). For treatment with various atypical antipsychotics (AP), no significant differences were found in weight changes between men and women; during treatment using a combination of multi-receptor AP and metabolically neutral aripiprazole, a significant increase of BMI occurred in men, but not in women (p = 0.018).Men appear to be more prone to weight gain than women. |
| Databáze: | OpenAIRE |
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