Synthesis, antioxidative and antiviral activity of hydroxycinnamic acid amides of thiazole containing amino acid
| Autor: | Ivanka Stankova, Stoyan Shishkov, Kiril Chuchkov, Luchia Mukova, Angel S. Galabov, Kalina Kostova |
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| Rok vydání: | 2008 |
| Předmět: |
Thiazole containing valine
DPPH test Coumaric Acids Free Radicals DPPH Herpesvirus 2 Human Clinical Biochemistry Herpesvirus 1 Human Coumaric acid Virus Replication Biochemistry Antiviral Agents p-Coumaric acid Antioxidants Cell Line Ferulic acid chemistry.chemical_compound Mice Picrates Pyridine Organic chemistry Animals Humans Antiviral activity Amino Acids Thiazole chemistry.chemical_classification Molecular Structure Organic Chemistry Biphenyl Compounds Antioxidant effect Free Radical Scavengers Hydroxycinnamic acid Hydroxycinnamides Amino acid Thiazoles chemistry Peptidomimetics |
| Zdroj: | Amino acids. 37(2) |
| ISSN: | 1438-2199 |
| Popis: | The synthesis and the biological (antioxidant and antiviral) activities of novel hydroxycinnamic acid amides of a thiazole containing TFA.valine-4-carboxylic acid ethyl ester are reported. The amides have been synthesized from p-coumaric, ferulic and sinapic acids with the corresponding TFA.valine-thiazole-4-carboxylic acid ethyl ester using the coupling reagent N-ethyl-N′-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-(dimethylamino) pyridine (DMAP) as a catalyst. The antioxidant properties of the newly synthesized amides have been studied for then antioxidative activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH)* test. The newly synthesized compounds have been tested against the replication in vitro of influenza virus A (H3N2) and human herpes virus 1 and 2 (HSV-1 and HSV-2). |
| Databáze: | OpenAIRE |
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