Deep brain stimulation in the medial septum attenuates temporal lobe epilepsy via entrainment of hippocampal theta rhythm

Autor: Ying Wang, Heming Cheng, Jie Yu, Xiaohua Wu, Xiang Fan, Cong Chen, Zhong Chen, Jinggen Liu, Yi Wang, Na Tan, Shuang Wang, Bei Tan, Xianhui Cai, Yating Shen
Rok vydání: 2021
Předmět:
0301 basic medicine
Drug Resistant Epilepsy
Deep Brain Stimulation
medicine.medical_treatment
Stimulation
Hippocampal formation
Hippocampus
Mice
Epilepsy
Cognition
0302 clinical medicine
Pharmacology (medical)
Theta Rhythm
Kainic Acid
Psychiatry and Mental health
Atropine
surgical procedures
operative
Original Article
therapeutics
medicine.drug
Deep brain stimulation
behavioral disciplines and activities
Temporal lobe
03 medical and health sciences
medial septum
Memory
Seizures
Physiology (medical)
Kindling
Neurologic
medicine
Animals
Learning
cognitive function
Pharmacology
business.industry
Original Articles
medicine.disease
Entrainment (biomusicology)
nervous system diseases
Mice
Inbred C57BL
030104 developmental biology
Epilepsy
Temporal Lobe
nervous system
epilepsy
Septum of Brain
business
Neuroscience
Psychomotor Performance
030217 neurology & neurosurgery
Zdroj: CNS Neuroscience & Therapeutics
ISSN: 1755-5949
1755-5930
DOI: 10.1111/cns.13617
Popis: Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the most common types of medically refractory epilepsy. Deep brain stimulation (DBS) shows considerable promise for the treatment of TLE. However, the optimal stimulation targets and parameters of DBS to control seizures and related cognitive impairment are still not fully illustrated. Methods In the present study, we evaluated the therapeutic potential of DBS in the medial septum (MS) on seizures and cognitive function in mouse acute and chronic epilepsy models. Results We found that DBS in the MS alleviated the severity of seizure activities in both kainic acid‐induced acute seizure model and hippocampal‐kindled epilepsy model. DBS showed antiseizure effects with a wide window of effective stimulation frequencies. The antiseizure effects of DBS were mediated by the hippocampal theta rhythm, as atropine, which reversed the DBS‐induced augmentation of the hippocampal theta oscillation, abolished the antiseizure effects of DBS. Further, in the kainic acid‐induced chronic TLE model, DBS in the MS not only reduced spontaneous seizures, but also improved behavioral performance in novel object recognition. Conclusion DBS in the MS is a promising approach to attenuate TLE probably through entrainment of the hippocampal theta rhythm, which may be therapeutically significant for refractory TLE treatment.
Here, we inferred that the DBS in the MS may be therapeutically significant for the treatment of refractory TLE. DBS in the MS not only alleviated seizures activities, but also improved behavioral performance in memory tests, via the enhancement of hippocampal theta rhythm.
Databáze: OpenAIRE
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