Meningitis and a safe dexamethasone-eluting intracochlear electrode array
| Autor: | L M Adams, Scott Chambers, Ya Lang Enke, Benjamin P. C. Wei, Stephen O'Leary, Robert Cowan, Christopher Miller, Carrie Newbold, Dimitra Stathopoulos, Roy M. Robins-Browne |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Prosthesis-Related Infections medicine.drug_class medicine.disease_cause Dexamethasone Microbiology Speech and Hearing Streptococcus pneumoniae medicine Electrode array Animals Prosthesis-Related Infection Rats Wistar Glucocorticoids Colony-forming unit Potential risk business.industry Meningitis Pneumococcal medicine.disease Cochlear Implantation Rats Cochlear Implants Otorhinolaryngology Immunology Corticosteroid business Meningitis medicine.drug |
| Zdroj: | Cochlear implants international. 16(4) |
| ISSN: | 1754-7628 |
| Popis: | To evaluate the potential risk of pneumococcal meningitis associated with the use of a dexamethasone-eluting intracochlear electrode array as compared with a control array.In two phases, adult Hooded-Wistar rats were implanted via the middle ear with an intracochlear array and were inoculated with Streptococcus pneumoniae 5 days post-surgery. Phase I created a dosing curve by implanting five groups (n = 6) with a control array, then inoculating 5 days later with different numbers of S. pneumoniae: 0 CFU, 10(3) CFU, 10(4) CFU, 10(4) CFU repeated, or 10(5) CFU (colony forming units). A target infection rate of 20% was aimed for and 10(4) CFU was the closest to this target with 33% infection rate. In phase II, we implanted two groups (n = 10), one with a dexamethasone-eluting array, the other a control array, and both groups were inoculated with 10(4) CFU of S. pneumoniae 5 days post-surgery.The dexamethasone-eluting array group had a 40% infection rate; the control array group had a 60% infection rate. This difference was not statistically significant with a P value of ≥0.5.The use of a dexamethasone-eluting intracochlear electrode array did not increase the risk of meningitis in rats when inoculated with S. pneumoniae via the middle ear 5 days following implantation. |
| Databáze: | OpenAIRE |
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