Utility of a proliferation marker in distinguishing between benign naevocellular naevi and naevocellular naevus-like lesions with malignant properties
| Autor: | B Lagerlöf, Johan Wejde, L Kanter, Harald Blegen, Olle Larsson |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Skin Neoplasms genetic structures business.industry Antibodies Monoclonal Nuclear Proteins Dermatology Immunohistochemistry Neoplasm Proteins Diagnosis Differential Ki-67 Antigen Oncology Humans Nevus Intradermal Medicine Proliferation Marker Neoplasm Recurrence Local skin and connective tissue diseases business Melanoma Nevus Cell Division |
| Zdroj: | Melanoma Research. 5:345-350 |
| ISSN: | 0960-8931 |
| Popis: | In the present study we have investigated the utility of the proliferation marker MIB 1 in distinguishing between benign naevocellular naevi and naevocellular naevus-like lesions with malignant potential. Percentages of MIB 1 immunoreactivity in the intradermal portion of the lesions were determined. In benign congenital and acquired naevi, as well as in dysplastic naevi, there was no or only a slight intradermal melanocytic proliferation (0-2%), whereas vertical growth phase melanomas exhibited a substantial proliferative activity (11-48%). In five cases of naevus-lke lesions, which had all relapsed as unmistakable malignant melanomas (locally or metastatically) after primary surgery, there was also clear proliferative activity (9-67%). Our findings suggest that MIB 1 may be a useful tool in the routine histopathological examination of problematic naevocellular lesions. |
| Databáze: | OpenAIRE |
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