Treatment of high risk medulloblastomas in children above the age of 3 years: A SFOP study
| Autor: | A. Lellouch Tubiana, C. Le Gales, Claire Alapetite, S. Bracard, J C Gentet, Véronique Mosseri, Christine Edan, Xavier Rialland, Anne Pagnier, D. Frappaz, Eric Sariban, Fabienne Pichon, Michel Zerah, Pascal Chastagner, D. Bours, Chantal Kalifa, François Doz, Anne-Isabelle Bertozzi, J. Verlooy |
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| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment Concordance Disease-Free Survival Carboplatin chemistry.chemical_compound Risk Factors Antineoplastic Combined Chemotherapy Protocols Humans Medicine Prospective Studies Cerebellar Neoplasms Child Prospective cohort study Etoposide Postoperative Care Medulloblastoma Chemotherapy business.industry medicine.disease Combined Modality Therapy Radiation therapy Treatment Outcome Oncology El Niño chemistry Child Preschool business medicine.drug |
| Zdroj: | European Journal of Cancer. 42:3004-3014 |
| ISSN: | 0959-8049 |
| Popis: | Aim Improvement of EFS of children older than 3 years with high risk medulloblastoma. Methods Between 1993 and 1999, 115 patients (3–18 years, mean 8 years) with high risk medulloblastoma were included. After surgery treatment consisted of chemotherapy (‘8in1’ and etoposide/carboplatin) before and after craniospinal radiotherapy. Results Patients were staged using Chang-criteria (PF residue only, M1 and M2/M3) by local investigator as well as by central review panel (82.4% concordance). Chemotherapy was well tolerated without major delays in radiotherapy. With a mean follow up of 81 months (9–119), 5-year EFS was 49.8% and OS 60.1%. In detail according to subgroups EFS was 68.8% for PF residue only, 58.8% for M1 disease and 43.1% for M2/M3. Conclusion M1 patients are legitimate high risk patients. Survival rates are still very low for high risk medulloblastoma patients and future trials should therefore focus on more intensive (chemotherapy/radiotherapy) treatment. |
| Databáze: | OpenAIRE |
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