The impact of one or two missed doses on the duration of action of combined perindopril and indapamide
| Autor: | Martin G. Myers, F H H Leenen |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Time Factors Missed Dose medicine.medical_treatment Pharmacology Placebo Double-Blind Method Internal Medicine medicine Perindopril Humans Thiazide Antihypertensive Agents business.industry Indapamide Middle Aged Ambulatory ACE inhibitor Hypertension Drug Therapy Combination Female Diuretic business medicine.drug |
| Zdroj: | Journal of human hypertension. 21(1) |
| ISSN: | 0950-9240 |
| Popis: | To evaluate the persistence of the antihypertensive effect of perindopril 4 mg+indapamide 1.25 mg once daily for up to 72 h using the 'missed-dose' technique. Hypertensive patients were initially treated with perindopril 2 mg+indapamide 0.625 mg once daily. After 4 weeks, the 135 of 216 patients who still had a diastolic BP> or =85 mm Hg went on to receive perindopril 4 mg+indapamide 1.25 mg daily for a further 8 weeks. During either week 9 or 11, placebo was substituted for perindopril 4 mg+indapamide 1.25 mg on either one or two consecutive days to simulate BP changes, which might occur after one or two missed doses. A 24-h ambulatory BP recording was performed at baseline, after 9 or 11 weeks of perindopril+indapamide therapy and during the simulated missed doses, 24- 48 and 48-72 h after the administration of perindopril 4 mg+indapamide 1.25 mg. Significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|