Hyperbaric oxygen as a prophylaxis for radiation-induced delayed enteropathy
| Autor: | Ivan Jelen, Martin L. Meltz, Rodica Alecu, David A. Davolt, Philip T. Valante, JJ Feldmeier |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Radiation induced Ileum Radiation enteropathy Mice Hyperbaric oxygen Ileocecal junction Intestine Small medicine Animals Radiology Nuclear Medicine and imaging Enteropathy Hyperbaric Oxygenation Mice Inbred C3H business.industry Hematology medicine.disease Surgery Radiation therapy Clinical trial Intestinal Diseases Radiation Injuries Experimental medicine.anatomical_structure Oncology Anesthesia Female business |
| Zdroj: | Radiotherapy and Oncology. 35:138-144 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/0167-8140(95)01544-q |
| Popis: | This trial was accomplished in C3H mice to determine whether hyperbaric oxygen (HBO) could be administered to prevent delayed radiation enteropathy. Fifty mice randomized into two equal groups received 30 Gy abdominopelvic irradiation in 10 fractions. The study group received a course of 30 HBO treatments beginning 7 weeks after the radiation exposure. The control group received only housing and nutritional support after irradiation. A third group of three animals had no radiation or HBO. All animals were sacrificed 7 months after radiation. Animals were inspected grossly for signs of enteropathy. In addition, a special stretch apparatus was used to quantify narrowing and rigidity of ileum just proximal to the ileocecal junction. Those animals who received HBO had fewer gross signs of enteropathy and had less narrowing and less rigidity in their harvested bowel segments. These differences were highly statistically significant. Treatment with HBO drastically reduces signs of radiation enteropathy. Further study including clinical trials are recommended. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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