Serum complement C4 in chronic hepatitis C: correlation with histopathologic findings and disease activity
| Autor: | Banu Bayraktar, Beşir Kesici, Canan Alkim, Mehmet Sait Bugdaci, Cetin Karaca, Mehmet Sokmen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Pathology Cirrhosis Hepatitis C virus Biopsy Fine-Needle Hepacivirus Chronic liver disease medicine.disease_cause Complement C3c Gastroenterology Transaminase Internal medicine medicine Humans Aspartate Aminotransferases Prospective Studies medicine.diagnostic_test business.industry Alanine Transaminase Complement C4 Hepatitis C Complement C3 gamma-Glutamyltransferase Hepatitis C Chronic Middle Aged medicine.disease Liver Liver biopsy Case-Control Studies Coinfection RNA business |
| Zdroj: | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 23(1) |
| ISSN: | 2148-5607 |
| Popis: | BACKGROUND/AIMS Hepatitis C virus leads to chronic liver disease, cirrhosis and hepatocellular cancer. Viral markers and other laboratory tests used in the diagnosis and follow-up of chronic hepatitis C do not correlate well with disease activity and liver histopathology. Therefore, alternative tests that indicate disease activity and relate with liver biopsy findings are needed. We aimed to investigate the relationship between serum complement levels and biopsy findings in patients with chronic hepatitis C. METHODS One hundred cases (70 patients, 30 healthy controls) were included in the study. Patients were divided into two groups: chronic hepatitis C patients with high transaminase levels were evaluated as the first group and patients with normal transaminase levels as the second group. Patients with a high transaminase level were biopsied and activity scores were evaluated against complement C3c and C4 levels. In addition, demographic data and laboratory tests were evaluated. Patients with chronic hepatitis C without proteinuria, acute phase response, cirrhosis, or coinfection with another hepatitis virus were included in the prospective study. RESULTS Serum complement C3c (p |
| Databáze: | OpenAIRE |
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