Persistent Fetal Sinus Bradycardia Associated with Maternal Anti-SSA/Ro and Anti-SSB/La Antibodies
| Autor: | Lukas A. J. Rammeloo, Sally-Ann B. Clur, Margot M. Bartelings, Priya Chockalingam, Johannes M.P.J. Breur, Monique C. Haak, Nico A. Blom, Edgar Jaeggi, Phebe N. Adama van Scheltema |
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| Přispěvatelé: | Paediatric Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Pediatric surgery, Obstetrics and gynaecology, ICaR - Heartfailure and pulmonary arterial hypertension |
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty PROGNOSIS FETUS Heart block Sinus bradycardia Immunology HEART BLOCK Autoantigens Rheumatology Pregnancy Internal medicine Bradycardia medicine Humans Immunology and Allergy Child Sinus (anatomy) Sick Sinus Syndrome Fetus business.industry Endocardial fibroelastosis medicine.disease medicine.anatomical_structure Ribonucleoproteins In utero Antibodies Antinuclear Child Preschool SINUS BRADYCARDIA Cardiology Female AUTOANTIBODIES Histopathology medicine.symptom business Anti-SSA/Ro autoantibodies |
| Zdroj: | Journal of rheumatology, 38(12), 2682-2685. Journal of Rheumatology Chockalingam, P, Jaeggi, E T, Rammeloo, L A J, Haak, M C, van Scheltema, P N A, Breur, J M P J, Bartelings, M M, Clur, S A B & Blom, N A 2011, ' Persistent Fetal Sinus Bradycardia Associated with Maternal Anti-SSA/Ro and Anti-SSB/La Antibodies ', Journal of Rheumatology, vol. 38, no. 12, pp. 2682-2685 . https://doi.org/10.3899/jrheum.110720 Journal of Rheumatology, 38(12), 2682-2685. Journal of Rheumatology |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.110720 |
| Popis: | Objective.To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction.Methods.We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies.Results.Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker.Conclusion.Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement. |
| Databáze: | OpenAIRE |
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