Enhancement of immobility induced by repeated phencyclidine injection: association with c-Fos protein in the mouse brain
| Autor: | Hiroshi Furukawa, Yukihiro Noda, Taku Nagai, Toshitaka Nabeshima, Moustafa Mahmoud Hamdy, Takayoshi Mamiya, Merfat Sayed |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system Phencyclidine Mice Inbred Strains Motor Activity Brain mapping Mice Behavioral Neuroscience Retrosplenial cortex Piriform cortex Internal medicine medicine Animals Premovement neuronal activity Swimming Brain Mapping Motivation Brain medicine.anatomical_structure Endocrinology Cerebral cortex Psychology Proto-Oncogene Proteins c-fos Neuroscience medicine.drug Behavioural despair test |
| Zdroj: | Behavioural Brain Research. 124:71-76 |
| ISSN: | 0166-4328 |
| Popis: | Immunohistochemistry of c-Fos protein was performed to study changes in neuronal activity in discrete brain areas of mice repeatedly treated with phencyclidine (PCP) showing enhancement of immobility in the forced swimming test, this behavioral change being considered as avolition, which is one of negative symptoms of schizophrenia. Repeated treatment with PCP significantly prolonged immobility time in the forced swimming test, compared with saline treatment. The c-Fos protein expression of mice showing PCP-induced enhancement of immobility was increased in certain brain regions, such as the retrosplenial cortex, pyriform cortices, pontine nuclei, cingulate, frontal cortex and thalamus, compared with that of PCP-treated, non-swimming and saline-treated, swimming groups. These results suggest that increased c-Fos protein is involved in the expression of PCP-induced enhancement of immobility, and c-Fos expression plays a role in negative symptoms-like behavioral changes. |
| Databáze: | OpenAIRE |
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