Association of microalbuminuria with left ventricular dysfunction in Nigerian normotensive type 2 diabetes patients
| Autor: | Joseph John Andy, T T Shogade, Udeme E. Ekrikpo, B C Unadike, I O Essien, I O Umoh, Clement Tom Utin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases Cross-sectional study Diastole Nigeria Type 2 diabetes Urinalysis Ventricular Function Left Test strips Ventricular Dysfunction Left Risk Factors Internal medicine Diabetes mellitus Prevalence Albuminuria Humans Medicine Risk factor Reagent Strips business.industry Cardiovascular Topics Case-control study General Medicine Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Echocardiography Case-Control Studies Cardiology Female Microalbuminuria Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovasc J Afr |
| ISSN: | 1680-0745 1995-1892 |
| DOI: | 10.5830/cvja-2018-026 |
| Popis: | BACKGROUND: Diabetes mellitus (DM) is a risk factor for left ventricular (LV) dysfunction, and microalbuminuria is frequently associated with DM. This study aimed to compare LV function among normotensive type 2 diabetes (T2DM) patients with normoalbuminuria, those with microalbuminuria, and healthy controls. METHODS: This was a cross-sectional study conducted at the diabetes and cardiology clinics of the University of Uyo Teaching Hospital, Uyo, Akwa-Ibom State, Nigeria, from January 2013 to March 2014. Microalbuminuria was tested for using Micral test strips, and echocardiography-derived indices of LV function were compared among the three groups. RESULTS: Sixty-three normoalbuminuric, 71 microalbuminuric T2DM patients and 59 healthy controls were recruited. Mean age of participants was 50 ± 8 years and the three groups were age and gender matched (p = 0.23, p = 0.36, respectively). LV diastolic dysfunction (LVDD) showed a stepwise increase from the healthy controls to the normoalbuminuric to the microalbuminuric T2DM patients (16.9 vs 61.9 vs 78.9%, respectively) (p < 0.001), while E/A ratio and fractional shortening showed a significant stepwise decrease (both p < 0.001). LV systolic dysfunction was rare among the three groups. Microalbuminuria showed a strong direct association with LVDD (OR 3.58, 95% CI: 1.99–6.82, p < 0.001). Age remained independently associated with LVDD (OR 1.10, 95% CI: 1.03–1.17, p = 0.003). CONCLUSIONS: LV diastolic function was altered in Nigerian normotensive T2DM patients, and the presence of microalbuminuria with DM had additional effects on this abnormality. Early screening for DM and microalbuminuria could identify individuals with high cardiovascular risk and possibly abnormal LV function. |
| Databáze: | OpenAIRE |
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