Anemia in Patients with Severe Aortic Stenosis

Autor: Current As Registry Investigators, Shintaro Matsuda, Yuichi Kawase, Tomoyuki Murakami, Takeshi Kitai, Kozo Hotta, Mamoru Toyofuku, Tomoyuki Ikeda, Yuko Morikami, Takeshi Morimoto, Eri Minamino-Muta, Akihiro Komasa, Moriaki Inoko, Mitsuru Ishii, Chiyo Maeda, Makoto Miyake, Yasutaka Inuzuka, Kenji Ando, Chisato Izumi, Hiroki Shiomi, Kazuya Nagao, Norio Kanamori, Naritatsu Saito, Katsuhisa Ishii, Keiichiro Yamane, Masashi Kato, Tsukasa Inada, Toshikazu Jinnai, Nobuya Higashitani, Kenji Minatoya, Hirokazu Mitsuoka, Takao Kato, Yoshihiro Kato, Tomohiko Taniguchi, Yutaka Hirano, Koichiro Murata, Yasuyo Takeuchi, Takeshi Kimura
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
ISSN: 2045-2322
Popis: Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the impact of anemia on cardiovascular and bleeding outcomes in 3403 patients enrolled in the CURRENT AS registry. 835 patients (25%) had mild (hemoglobin 11.0–12.9 g/dl for men/11.0–11.9 g/dl for women) and 1282 patients (38%) had moderate/severe anemia (Hb ≤ 10.9 g/dl) at diagnosis of severe AS. Mild and moderate/severe anemia were associated with significantly increased risks relative to no anemia (hemoglobin ≥13.0 g/dl for men/≥12.0 g/dl for women) for the primary outcome measure (aortic valve-related death or heart failure hospitalization) in the entire population [hazard ratio (HR): 1.30; 95% confidence interval (CI): 1.07–1.57 and HR: 1.56; 95%CI: 1.31–1.87, respectively] and in the conservative management stratum (HR: 1.73; 95%CI: 1.40–2.13 and HR: 2.05; 95%CI: 1.69–2.47, respectively). Even in the initial aortic valve replacement stratum, moderate/severe anemia was associated with significantly increased risk for the primary outcome measure (HR: 2.12; 95%CI: 1.44–3.11). Moreover, moderate/severe anemia was associated with significantly increased risk for major bleeding while under conservative management (HR: 1.93; 95%CI: 1.21–3.06). These results warrant further study to explore whether better management of anemia would lead to improvement of clinical outcomes.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje