Hepatic Coma in Liver Failure and Gastro-intestinal Haemorrhage Treated with Neomycin
| Autor: | W. H. J. Summerskill |
|---|---|
| Rok vydání: | 1958 |
| Předmět: |
medicine.medical_specialty
Hemorrhage Gastroenterology Liver disease Internal medicine medicine Humans Hepatic encephalopathy General Environmental Science Coma Gastrointestinal tract business.industry General Engineering Liver failure Neomycin Articles General Medicine medicine.disease Hepatic coma Surgery Gastrointestinal Tract Hepatic Encephalopathy General Earth and Planetary Sciences medicine.symptom Gastrointestinal Hemorrhage business Liver Failure Gastro intestinal medicine.drug |
| Zdroj: | BMJ. 2:1322-1325 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.2.5108.1322 |
| Popis: | The introduction of protein withdrawal, oral broad spectrum antibiotics, and enemata as a basis for treating hepatic impending coma and coma (Sherlock et al, 1954) has been supported by encouraging results in larger groups of patients (Sherlock et al., 1956 ; Summerskill et al., 1957a). However, the relative contribution of each measure to the therapeutic response is uncertain, and protein deprivation, which may have to be long continued, is particularly undesirable when liver disease is associated with undernutrition. No comparative studies are available to indicate the most effective anti biotic in hepatic coma, but the recent use of neomycin in three patients by Fisher and Faloon (1957) is important, as temporary clinical improvement was com patible with continued protein administration. Dawson et al. (1957) treated acute hepatic coma in 12 patients with neomycin, protein deprivation, and other measures. No conclusions were drawn in regard to its specific therapeutic action in either series, as coma was often due to multiple factors and additional methods of treat ment were employed simultaneously. In this paper the effect of neomycin is compared with that of other anti biotics under controlled conditions, and the degree to which protein withdrawal and other procedures may be modified as a result of neomycin therapy is also studied. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|