Mitochondrial proteome analysis reveals depression of the Ndufs3 subunit and activity of complex I in diabetic rat brain
| Autor: | Raffaella Trentadue, Antonio Gnoni, Federica Taurino, Luisa Siculella, Eleonora Stanca, Sergio Papa, Franco Zanotti |
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| Přispěvatelé: | Taurino, F, Stanca, Eleonora, Siculella, Luisa, Trentadue, R, Papa, S, Zanotti, F, Gnoni, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Diabetic encephalopathy Proteome Diabetic rat Protein subunit Biophysics Down-Regulation Mitochondrial complex I Biology Models Biological Biochemistry Streptozocin Diabetes Mellitus Experimental Mitochondrial Proteins Internal medicine Diabetes mellitus Type-1 diabete medicine Animals Rats Wistar Depression (differential diagnoses) Brain Chemistry chemistry.chemical_classification Type 1 diabetes Messenger RNA Electron Transport Complex I Brain Diseases Metabolic Brain NADH Dehydrogenase Brain mitochondrial proteome medicine.disease Ndufs3 subunit Rats Enzyme Activation Protein Subunits Diabetes Mellitus Type 1 Enzyme Endocrinology chemistry |
| Popis: | Type-1 diabetes resulting from defective insulin secretion and consequent hyperglycemia, is associated with “diabetic encephalopathy.” This is characterized by brain neurophysiological and structural changes resulting in impairment of cognitive function. The present proteomic analysis of brain mitochondrial proteins from streptozotocin-induced type-1 diabetic rats, shows a large decrement of the Ndufs3 protein subunit of complex I, decreased level of the mRNA and impaired catalytic activity of the complex in the diabetic rats as compared to controls. The severe depression of the expression and enzymatic activity of complex I can represent a critical contributing factor to the onset of the diabetic encephalopathy in type-1 diabetes. |
| Databáze: | OpenAIRE |
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