Passive Immunization with LINGO-1 Polyclonal Antiserum Afforded Neuroprotection and Promoted Functional Recovery in a Rat Model of Spinal Cord Injury
| Autor: | Yi-quan Ke, Yanjun Zeng, Mouxuan Du, Yu-xi Zou, Ying-qian Cai, Chang-chen Hu, Xiao-dan Jiang, Jun Lv, Ling-sha Qin, Xin Lu, Ru-xiang Xu |
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| Rok vydání: | 2010 |
| Předmět: |
Receptor complex
RHOA Cell Survival Immunology Nerve Tissue Proteins Biology Pharmacology Neuroprotection Rats Sprague-Dawley Endocrinology medicine Animals Paralysis Axon Spinal cord injury Injections Spinal Spinal Cord Injuries Antiserum Endocrine and Autonomic Systems Immune Sera Immunization Passive Membrane Proteins Recovery of Function Spinal cord medicine.disease Rats Disease Models Animal Treatment Outcome medicine.anatomical_structure Neurology Cytoprotection Polyclonal antibodies Nerve Degeneration biology.protein Female rhoA GTP-Binding Protein |
| Zdroj: | Neuroimmunomodulation. 17:270-278 |
| ISSN: | 1423-0216 1021-7401 |
| DOI: | 10.1159/000290043 |
| Popis: | LINGO-1 (leucine-rich repeat and Ig domain-containing, Nogo receptor-interacting protein) is an important component of the NgR receptor complex involved in RhoA activation and axon regeneration. The authors report on passive immunization with LINGO-1 polyclonal antiserum, a therapeutic approach to overcome NgR-mediated growth inhibition after spinal cord injury (SCI). The intrathecally administered high-titer rabbit-derived antiserum can be detected around the injury site within a wide time window; it blocks LINGO-1 in vivo with high molecular specificity. In this animal model, passive immunization with LINGO-1 antiserum significantly decreased RhoA activation and increased neuronal survival. Adult rats immunized in this manner show recovery of certain hindlimb motor functions after dorsal hemisection of the spinal cord. Thus, passive immunotherapy with LINGO-1 polyclonal antiserum may represent a promising repair strategy following acute SCI. |
| Databáze: | OpenAIRE |
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