Pretreatment diagnosis factors associated with overtreatment with surgery in patients with differentiated-type early gastric cancer

Autor:	Tomohiro Tsuchida, Masatsugu Nagahama, Toshiaki Hirasawa, Satoshi Ida, Junko Fujisaki, Hiroshi Takahashi, Toshiyuki Yoshio, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Yorimasa Yamamoto, Noriko Yamamoto
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Adult Male Surgical resection medicine.medical_specialty lcsh:Medicine Medical Overuse Article 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Humans Medicine Endoscopic resection In patient Diagnostic Errors lcsh:Science Pathological Early Detection of Cancer Aged Aged 80 and over Multidisciplinary business.industry lcsh:R Cell Differentiation Retrospective cohort study Histology Middle Aged Surgery Early Gastric Cancer 030220 oncology & carcinogenesis Multivariate Analysis Female 030211 gastroenterology & hepatology lcsh:Q Gastric cancer business Tumour diameter
Zdroj:	Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific Reports
ISSN:	2045-2322
Popis:	This study aimed to clarify the pretreatment factors associated with overtreatment with surgery in patients with differentiated-type early gastric cancer. This single-centre, retrospective study included 781 patients with differentiated-type early gastric cancer treated by surgical resection between April 2005 and May 2017. Postoperative pathological results were used to divide patients into the accurate surgical indication group and overtreatment with surgery group; the groups were compared with respect to accurate diagnosis and misdiagnosis based on tumour diameter (≤30 mm or >30 mm), diagnosis of depth, diagnosis of ulcerative findings, and diagnosis of main histology. There were 224 patients in the overtreatment with surgery group. Multivariate analysis revealed significant differences in misdiagnosis of tumour diameter, misdiagnosis of depth, misdiagnosis of ulcerative findings, and misdiagnosis of main histology between the accurate surgical indication group and overtreatment with surgery group. Significant factors for pretreatment misdiagnosis leading to overtreatment in differentiated-type early gastric cancer were tumour diameter, depth, and main histology. It may be acceptable to perform endoscopic resection for patients with pretreatment tumour diameter ≤30 mm, mucosal invasion of pretreatment depth, and undifferentiated-type cancers containing differentiated-type components of pretreatment histology because this reduces overtreatment with surgery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f959435f8c59d6f1c90b306d652bf8da http://link.springer.com/article/10.1038/s41598-019-51952-w Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.