Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Autor: Jean Bousquet, Harold James Wedner, Ebenezer Satyaraj
Přispěvatelé: Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Allergen immunotherapy
Allergy
Immunology
Immunoglobulins
Chick Embryo
cat allergies
Epitopes
03 medical and health sciences
0302 clinical medicine
Fel d 1
Blocking antibody
medicine
Care pathway
Animals
Humans
Immunology and Allergy
[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology
Saliva
Glycoproteins
Asthma
anti‐Fel d1 IgY
biology
Allergy to cats
business.industry
Pets
Allergens
Immunoglobulin E
medicine.disease
Antibodies
Neutralizing
Rhinitis
Allergic
Diet
3. Good health
Publication of this supplement is made possible by the Purina Institute
blocking antibodies
030104 developmental biology
030228 respiratory system
Desensitization
Immunologic
Cats
biology.protein
[SDV.IMM]Life Sciences [q-bio]/Immunology
Supplement Article
Cat allergen
business
Protein Binding
Zdroj: Allergy
Allergy, Wiley, 2019, 74 (S107), pp.5-17. ⟨10.1111/all.14013⟩
ISSN: 0105-4538
1398-9995
Popis: International audience; BACKGROUND:Allergies to cats are the most common animal-origin allergy, and affect approximately 1 in 5 adults worldwide. The prevalence of allergy to furry animals has been increasing, and allergy to cats is a major risk factor for the development of asthma and rhinitis. The diagnosis of cat allergy is now well established. The exact significance of component-resolved diagnosis in the diagnosis of cat allergy remains to be fully understood. Allergen avoidance is effective but often has a psychologic impact. Allergen immunotherapy is not well demonstrated. There is a need for innovative approaches to better manage cat allergens. Next-generation care pathways for asthma and rhinitis will define the place of cat allergen avoidance.METHODS AND RESULTS:This manuscript, based on content presented at the European Academy of Allergy and Clinical Immunology Congress 2019, provides information on the prevalence and impact of cat allergies and the molecular biology of Fel d 1, the major cat allergen.DISCUSSION:The authors present the scientific basis of a novel care pathway that utilizes anti-Fel d 1 IgY antibodies to safely and effectively neutralize Fel d 1 after its production by the cat but before human exposure.CONCLUSION:Efficacy of a feline diet with an egg product ingredient containing anti-Fel d 1 IgY antibodies was demonstrated in vitro, ex vivo, and in vivo, and further validated by a pilot exposure study involving cat-allergic human participants.
Databáze: OpenAIRE
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