Marked increase of serum hepatitis C virus (HCV) RNA titer during treatment with high-dose prednisolone in a case of polymyositis
| Autor: | Takuya Shiroma, Masao Tadokoro, Junko Fukuda, Ryuichi Yokohari, Takahiro Okai, Takashi Kato |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Prednisolone Hepatitis C virus medicine.medical_treatment Hepacivirus medicine.disease_cause Polymyositis Transaminase Rheumatology Internal medicine Hyperviscosity syndrome Humans Medicine Glucocorticoids Aged business.industry Immunosuppression General Medicine Hepatitis C Chronic medicine.disease Titer Immunology RNA Viral Female business medicine.drug |
| Zdroj: | Clinical Rheumatology. 24:182-186 |
| ISSN: | 1434-9949 0770-3198 |
| DOI: | 10.1007/s10067-004-1020-6 |
| Popis: | A 70-year-old Japanese woman with hepatitis C virus (HCV) infection was diagnosed with polymyositis and treated with high-dose prednisolone (PSL). The serum alanine aminotransferase (ALT) level increased from 78 to 345 U/l 1 week after initiating treatment, although the polymyositis settled promptly. Furthermore, the serum HCV RNA level increased markedly from 110 to 850 kIU/ml 3 weeks after starting treatment. Previously, the patient had suffered an occlusion of the left branch of the retinal vein secondary to hyperviscosity syndrome resulting from Sjögren's syndrome and low-dose PSL treatment had been commenced. The serum HCV RNA and transaminase levels had not increased during this low-dose PSL treatment. Although intensive immunosuppression is necessary as an initial treatment of several collagen diseases including polymyositis, high-dose PSL therapy may markedly augment the serum HCV RNA level and therefore careful observation is necessary in HCV-infected patients. |
| Databáze: | OpenAIRE |
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