Recombinant Allergens for Diagnosis of Cockroach Allergy
Autor: | Michelle C.R. Barbosa, L. Karla Arruda, Adriana S. Moreno, A.B.R. Santos, Anna Pomés, Martin D. Chapman |
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Rok vydání: | 2014 |
Předmět: |
Pulmonary and Respiratory Medicine
endocrine system Allergy medicine.medical_treatment Immunology Cockroaches Cross Reactions Molecular cloning Immunoglobulin E Article law.invention immune system diseases law biology.animal medicine Animals Humans Immunology and Allergy Sensitization Skin Tests Asthma Cockroach biology Immunotherapy Allergens biochemical phenomena metabolism and nutrition respiratory system medicine.disease Recombinant Proteins PROTEÍNAS RECOMBINANTES respiratory tract diseases medicine.anatomical_structure biology.protein Recombinant DNA |
Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
ISSN: | 1534-6315 1529-7322 |
Popis: | Molecular cloning of cockroach allergens and their expression as recombinant proteins have allowed a better understanding of the mechanisms of cockroach allergic disease. Recombinant cockroach allergens have been used for skin testing or in vitro methods to measure IgE antibody levels in serum. Early studies evaluating selected U.S. patients revealed that a cocktail of four cockroach allergens, Bla g 1, Bla g 2, Bla g 4, and Bla g 5, would identify 95 % of cockroach allergic patients. More recent studies pointed to an important role of sensitization to tropomyosin among certain populations, and suggested that a cocktail of five allergens Bla g 1 and/or Per a 1, Bla g 2, Bla g 4, Bla g 5, and Bla g 7, and/or Per a 7, would be expected to diagnose 50- 64 % of cockroach-allergic patients worldwide. Variation in IgE reactivity profiles could be in part due to IgE responses to cross-reactive homologous allergens from different origins. The availability of purified natural or recombinant cockroach allergens provides the capacity to improve diagnosis of cockroach allergy and to develop novel forms of immunotherapy for cockroach-allergic patients. |
Databáze: | OpenAIRE |
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