Synthesis of 'neoprofen', a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

Autor:	Gregory B. Dudley, Suresh Eyunni, Ron R. Ramsubhag, Elizabeth Mazzio, Christina M. Dadich, Andrew J. Janeczek, Chelsea Massaro, Tung T. Hoang, Karam F.A. Soliman
Rok vydání:	2016
Předmět:	Drug media_common.quotation_subject Ibuprofen 010402 general chemistry Topology 01 natural sciences Biochemistry Article medicine Humans Physical and Theoretical Chemistry Topology (chemistry) media_common Cyclooxygenase 2 Inhibitors Molecular Structure 010405 organic chemistry Chemistry Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Molecular Pharmacology Combinatorial chemistry 0104 chemical sciences Cyclooxygenase 2 Pharmaceutical Substances medicine.drug
Zdroj:	Organic & Biomolecular Chemistry. 14:7855-7858
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c6ob01351a
Popis:	3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a hydrophobic and rigid 3-D topology with distinct molecular pharmacology, as exemplified here with two neopentylene-fused analogues of the synthetic anti-inflammatory drug, ibuprofen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9554651b54008f6273812e433791e1e https://doi.org/10.1039/c6ob01351a Zobrazit plný text záznamu