OnabotulinumtoxinA injection towards the SPG for treating symptoms of refractory chronic rhinosinusitis with nasal polyposis: a pilot study
| Autor: | Daniel Fossum Bratbak, Irina Aschehoug, Lars Jacob Stovner, Erling Tronvik, Wenche Moe Thorstensen, Joan Vidal Crespi, Kent Are Jamtøy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Rhinorrhea Chronic rhinosinusitis Pilot Projects Injections Nasal Polyps Refractory medicine Humans Vidian nerve Prospective Studies Botulinum Toxins Type A Sinusitis Rhinitis business.industry General Medicine Middle Aged Botulinum toxin Dermatology Ganglion medicine.anatomical_structure Neuromuscular Agents Otorhinolaryngology Chronic Disease Female Pterygopalatine ganglion Nasal Obstruction business medicine.drug |
| Zdroj: | Acta Oto-Laryngologica |
| Popis: | Background and objective The main objective of this prospective, open, uncontrolled pilot study was to investigate the safety of administering onabotulinumtoxinA (BTA) towards the sphenopalatine ganglion (SPG) in 10 patients with refractory chronic rhinosinusitis with nasal polyposis (CRSwNP) using a novel injection tool, the MultiGuide®. Material and methods A one-month baseline period was followed by bilateral injections of 25 U BTA in the SPG and a follow-up of 12 weeks. The primary outcome was adverse events (AE), and the main efficacy outcome was a 50% reduction in visual analogue scale (VAS) symptoms for nasal obstruction and rhinorrhea in months 2 and 3 post-treatment compared to baseline. Results We registered 13 AEs, none of which were serious, however, one patient experienced diplopia which moderately affected his daily activities. The symptoms slowly improved and resolved 4 weeks after injection. Five patients were treatment responders with at least 50% median reduction in the nasal obstruction, and four were treatment responders concerning rhinorrhea. Conclusions Injection of BTA toward the SPG using the MultiGuide® in patients with CRSwNP appears to be safe but with a potential for moderately disabling side effects. The study indicates a beneficial effect on nasal obstruction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|