Gut microbiome signatures distinguish type 2 diabetes mellitus from non-alcoholic fatty liver disease

Autor: GwangPyo Ko, Won Kim, Seoyeon Park, Bon Jeong Ku, Sae Kyung Joo, Hyun Ju You, Jiyeon Si, Giljae Lee, Dong Hyeon Lee
Jazyk: angličtina
Rok vydání: 2021
Předmět:
endocrine system diseases
BMI
body mass index
Disease
Gut flora
Biochemistry
Gastroenterology
Structural Biology
LDL
low-density lipoprotein
Enterotype
biology
NASH-CRN
non-alcoholic steatohepatitis clinical research network
Fatty liver
Computer Science Applications
Cohort
LPS
lipopolysaccharide
Research Article
PICRUSt2
phylogenetic investigation of communities by reconstruction of unobserved states 2
Biotechnology
NAFLD
non-alcoholic fatty liver disease
medicine.medical_specialty
FDR
false discovery rate
NASH
non-alcoholic steatohepatitis
Biophysics
HbA1c
glycosylated hemoglobin
digestive system
MaAsLin2
microbiome multivariable association with linear models 2
Non-alcoholic fatty liver disease (NAFLD)
ALT
alanine aminotransferase
Diabetes mellitus
Internal medicine
T2D
type 2 diabetes mellitus
Type 2 diabetes mellitus
Genetics
medicine
NAFL
non-alcoholic fatty liver
Microbiome
FBS
fasting blood sugar
ComputingMethodologies_COMPUTERGRAPHICS
Gut microbiome
business.industry
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
Biomarker
medicine.disease
biology.organism_classification
digestive system diseases
business
FLI
fatty liver index
TP248.13-248.65
Zdroj: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5920-5930 (2021)
Computational and Structural Biotechnology Journal
ISSN: 2001-0370
Popis: Graphical abstract
Non-alcoholic fatty liver disease (NAFLD) is closely associated with type 2 diabetes mellitus (T2D), and these two metabolic diseases demonstrate bidirectional influences. The identification of microbiome profiles that are specific to liver injury or impaired glucose metabolism may assist understanding of the role of the gut microbiota in the relationship between NAFLD and T2D. Here, we studied a biopsy-proven Asian NAFLD cohort (n = 329; 187 participants with NAFLD, 101 with NAFLD and T2D, and 41 with neither) and identified Enterobacter, Romboutsia, and Clostridium sensu stricto as the principal taxa associated with the severity of NAFLD and T2D, whereas Ruminococcus and Megamonas were specific to NAFLD. In particular, the taxa that were associated with both severe liver pathology and T2D were also significantly associated with markers of diabetes, such as fasting blood glucose and Hb1Ac. Enterotype analysis demonstrated that participants with NAFLD had a significantly higher proportion of Bacteroides and a lower proportion of Ruminococcus than a Korean healthy twin cohort (n = 756). However, T2D could not be clearly distinguished from NAFLD. Analysis of an independent T2D cohort (n = 185) permitted us to validate the T2D-specific bacterial signature identified in the NAFLD cohort. Functional inference analysis revealed that endotoxin biosynthesis pathways were significantly enriched in participants with NAFLD and T2D, compared with those with NAFLD alone. These findings may assist with the development of effective therapeutic approaches for metabolic diseases that are associated with specific bacterial signatures.
Databáze: OpenAIRE
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