Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis
| Autor: | Nuket Mas, Ilker Tasci, Mehmet Refik Mas, Ramazan Ocal, Bilgin Comert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty medicine.medical_treatment CCL4 Mitochondrion Biology Endoplasmic Reticulum Rats Sprague-Dawley chemistry.chemical_compound Microscopy Electron Transmission Fibrosis Internal medicine medicine Animals skin and connective tissue diseases Saline Carbon Tetrachloride Organelles Endoplasmic reticulum Ursodeoxycholic Acid Gastroenterology General Medicine medicine.disease Ursodeoxycholic acid Rats Endocrinology medicine.anatomical_structure chemistry Biochemistry Hepatocyte Carbon tetrachloride Hepatocytes sense organs Rapid Communication medicine.drug |
| Popis: | AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers. METHODS: Liver fibrosis was induced in male SpragueDawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group Ⅱ with UDCA (25 mg/kg per day) for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes were evaluated according to a scoring system. RESULTS: Mitochondria, nuclei, RER and SER injury scores in group Ⅱ were significantly lower than those in groupⅠ(P < 0.001). CONCLUSION: UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis. |
| Databáze: | OpenAIRE |
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