Hypocholesterolemic effect of bile acid sulfonate analogs in hamsters
| Autor: | Hyun-Guell Kim, Taiju Kuramoto, Mizuho Une, Mitsuhide Noshiro, Kingo Fujimura |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Taurine medicine.drug_class Hypercholesterolemia Pharmaceutical Science Chenodeoxycholic Acid Bile Acids and Salts chemistry.chemical_compound Internal medicine Cricetinae medicine Animals Cholesterol 7-alpha-Hydroxylase Pharmacology Bile acid biology Mesocricetus Cholesterol Gallbladder Anticholesteremic Agents Body Weight Ursodeoxycholic Acid Cholic acid Biological activity Cholic Acids General Medicine Organ Size Enzyme assay Endocrinology medicine.anatomical_structure chemistry Liver Glycine biology.protein |
| Zdroj: | Biologicalpharmaceutical bulletin. 24(3) |
| ISSN: | 0918-6158 |
| Popis: | We studied the effects of bile acid sulfonate analogs, namely, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholane-24-sulfonate (C-sul), 3alpha,7alpha-dihydroxy-5beta-cholane-24-sulfonate (CDC-sul), and 3alpha,7beta-dihydroxy-5beta-cholane-24-sulfonate (UDC-sul), on serum and liver cholesterol levels, cholesterol 7alpha-hydroxylase activity, and biliary bile acid composition in hamsters fed cholesterol. Of the three analogs studied, UDC-sul slightly but significantly decreased free, esterified, and total cholesterol concentrations in the serum. UDC-sul and CDC-sul reduced liver total cholesterol levels by 25% and 18%, respectively, particularly in the esterified cholesterol fraction. Analysis of biliary bile acids showed the presence of the administered analogs, indicating that sulfonate analogs efficiently participate in enterohepatic cycling. The proportion of cholic acid was increased in all groups fed sulfonate analogs, but the ratio of glycine to taurine conjugated bile acids (G/T) was elevated only in UDC-sul feeding hamsters. There was no significant change in cholesterol 7alpha-hydroxylase activity in hamsters fed C-sul or CDC-sul, while UDC-sul slightly stimulated the enzyme activity compared to the control. The UDC-sul induced decrease in serum and liver cholesterol concentrations may be secondary to enhanced bile acid synthesis. This is supported by the increased cholesterol 7alpha-hydroxylase activity and elevated G/T ratio in biliary bile acids observed following UDC-sul administration. |
| Databáze: | OpenAIRE |
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