Racemic indole alkaloids from the seeds of Peganum harmala
| Autor: | Kai-Bo Wang, Hui-Ming Hua, Zhan-Lin Li, Dahong Li, Sheng-Ge Li, Jiao Bai, Xu Hu, Xin-Yu Li, Yue-Hu Pei |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Indole test Molecular Structure Indole alkaloid biology 010405 organic chemistry Chemistry Stereochemistry Alkaloid Carbon skeleton Microbial Sensitivity Tests General Medicine 010402 general chemistry biology.organism_classification 01 natural sciences Indole Alkaloids 0104 chemical sciences Peganum harmala Cell Line Tumor Seeds Drug Discovery Humans Peganum Enantiomer |
| Zdroj: | Fitoterapia. 125:155-160 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2018.01.008 |
| Popis: | Five pairs of new 2-oxoindole alkaloids, (±)-peganumalines A-E (1-5), and a new indole alkaloid, peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calculations. Notably, (±)-peganumalines A (1) represent a pair of rare 2-oxoindole dimeric alkaloid enantiomer with the hitherto unknown carbon skeleton. All isolates were tested for antiproliferative and antibacterial activities. |
| Databáze: | OpenAIRE |
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