Chronic administration of methylphenidate did not affect memory and GDNF levels but increase astrogliosis in adult male rat's hippocampus
| Autor: | Maral Moafi, Hossein Toreyhi, Hojjat-Allah Abbaszadeh, Mahdi Eskandarian Boroujeni, Ali Forouzannia, Gholam Hossein Meftahi, Tahmineh Peirouvi, Farid Fotouhi, Samira Ezi, Fakhroddin Aghajanpour, Seyed Hamidreza Mirbehbahani, Abbas Aliaghaei |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Motor Activity Hippocampus 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Neurotrophic factors Memory Internal medicine mental disorders medicine Glial cell line-derived neurotrophic factor Hippocampus (mythology) Animals Glial Cell Line-Derived Neurotrophic Factor Gliosis Adverse effect Maze Learning biology Methylphenidate business.industry Long-term potentiation medicine.disease Barnes maze Astrogliosis Rats 030104 developmental biology Endocrinology biology.protein Central Nervous System Stimulants business human activities 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of chemical neuroanatomy. 108 |
| ISSN: | 1873-6300 |
| Popis: | Background ADHD is the most common developmental disorder affecting approximately three to seven percent of school-aged children and 2.5 percent of adults worldwide. The drug of choice for the pharmacotherapy of ADHD is Methylphenidate (MPH). However, there is growing concerns about side effects resulting from its potential interference with brain anatomical and behavioral development. Aim This article focuses on the adverse effects of MPH on the rat’s hippocampus. Methods The animals received an oral dose of 5 mg/kg MPH or normal saline, as the vehicle, on a daily basis for 30 days. Y-maze test, passive avoidance, Barnes maze and field potential recording were conducted. Western blot for detecting the neurotrophic factor of GDNF and immunohistochemistry of astrogliosis were performed. Results Our results revealed that MPH treatment suppressed the willingness of rats to explore new environments. Also, it had no effect on improving long-term potentiation, long-term memory and spatial memory in the MPH group as opposed to the control group. There was also a significant increase of astrogliosis in the treated rats’ hippocampi. On the other hand, there was not a significant relationship between MPH administration and the decrement of the GDNF level. Conclusion We encourage the need to conduct more research on the adverse effects of MPH on the brain. |
| Databáze: | OpenAIRE |
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