Cross-border outbreak of extensively drug-resistant tuberculosis linked to a university in Romania
| Autor: | M. Mansjo, Esther Robinson, H. Soini, E. Rorman, O. Popovici, D. Homorodean, P. J. Freidlin, Ph. Monk, D. I. Chiotan, Ramona Groenheit, Grace Smith, Daniel Chemtob, M J van der Werf, Marjo Haanperä |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Tuberculosis Students Medical Adolescent Epidemiology Extensively Drug-Resistant Tuberculosis 030106 microbiology Interferon gamma release assay Tuberculin Disease cluster Disease Outbreaks 03 medical and health sciences Young Adult 0302 clinical medicine medicine Cluster Analysis Humans Family 030212 general & internal medicine Israel business.industry Transmission (medicine) Romania Outbreak Extensively drug-resistant tuberculosis medicine.disease Europe Infectious Diseases Family medicine Female Contact Tracing business Contact tracing |
| Zdroj: | Epidemiology and infection. 146(7) |
| ISSN: | 1469-4409 |
| Popis: | Extensively drug-resistant (XDR) tuberculosis (TB) poses a threat to public health due to its complicated, expensive and often unsuccessful treatment. A cluster of three XDR TB cases was detected among foreign medical students of a Romanian university. The contact investigations included tuberculin skin testing or interferon gamma release assay, chest X-ray, sputum smear microscopy, culture, drug susceptibility testing, genotyping and whole-genome sequencing (WGS), and were addressed to students, personnel of the university, family members or other close contacts of the cases. These investigations increased the total number of cases to seven. All confirmed cases shared a very similar WGS profile. Two more cases were epidemiologically linked, but no laboratory confirmation exists. Despite all the efforts done, the source of the outbreak was not identified, but the transmission was controlled. The investigation was conducted by a team including epidemiologists and microbiologists from five countries (Finland, Israel, Romania, Sweden and the UK) and from the European Centre for Disease Prevention and Control. Our report shows how countries can collaborate to control the spread of XDR TB by exchanging information about cases and their contacts to enable identification of additional cases and transmission and to perform the source investigation. |
| Databáze: | OpenAIRE |
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