| Autor: |
Tokguen, Pervin Elvan, Tomatir, Ayşe Gaye |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi. |
| ISSN: |
1305-6441 |
| DOI: |
10.26650/iuitfd.1200910 |
| Popis: |
Objective: Breast cancer is associated with a 5% genetic predisposition in women. Mitochondria play a role in important cellular events such as metabolism, cell death, and inflammation. Recent studies have highlighted precursor micro-RNA (pre-miRNA) to be located in mitochondria as well as mature miRNA. This study aims to reveal the occurrence of mitochondrial miRNA (mitomiR) in breast cancer cells.Materials and Methods: The study has prepared the mitochondrial fractions using the magnetic-activated cell sorting (MACS) method and performed small RNA (sRNA) sequencing.Results: The study has identified known and novel mitomiR sequences aligned to the mitochondrial genome.Conclusion: Identifying new mitomiRs can provide significant contributions and illuminate the molecular mechanism underlying mitomiR biogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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