Oxidative stress and delta-ALA-D activity in chronic renal failure patients
| Autor: | Rosilene Rodrigues Kaizer, Maria Rosa Chitolina Schetinger, Adriane Cismoski da Silva, Vera Maria Morsch, Paula Acosta Maldonado, Rafael Fernandes Zanin, Luís C. Arantes, André L.B. Morsch, João Rocha, Luis Leopoldo Silva |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia medicine.medical_treatment medicine.disease_cause Lipid peroxidation chemistry.chemical_compound Hemoglobins Renal Dialysis Internal medicine medicine Humans Aged Uremia Pharmacology Aged 80 and over biology business.industry Porphobilinogen Synthase General Medicine Middle Aged medicine.disease Catalase Oxidative Stress Endocrinology chemistry Dehydratase biology.protein Kidney Failure Chronic Female Hemodialysis Hemoglobin Lipid Peroxidation business Oxidative stress |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 61(2-3) |
| ISSN: | 0753-3322 |
| Popis: | In this paper, we studied the influence of uremia and hemodialysis on oxidative parameters and delta-aminolevulinic acid dehydratase (delta-ALA-D) activity in control subjects, patients with chronic renal failure (CRF) on hemodialysis treatment (HD) and in patients not undergoing hemodialysis (ND). An increased lipid peroxidation was observed in the serum of HD and ND patients, as measured by the MDA serum levels. However, the level of MDA from erythrocytes was only elevated in HD patients. Blood catalase activity was increased in HD and ND groups. This study also showed a decreased activity of blood delta-aminolevulinic acid dehydratase (delta-ALA-D) in both groups of patients. This study demonstrated a positive correlation between ALA-D activity and hemoglobin, suggesting that inhibition of this enzyme might enhance anemia in CRF. A negative correlation was found between the alteration in delta-ALA-D activity and oxidative stress, which may indicate that the inhibition of ALA-D can be used as an index of oxidative stress. |
| Databáze: | OpenAIRE |
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