Hydroalcoholic extract of leaf of Arachis hypogaea L. (Fabaceae) did not induce toxic effects in the repeated-dose toxicity study in rats
| Autor: | Juliana Sorraila de Oliveira, Amanda Spring de Almeida, Maria Carolina Theisen, Alencar Kolinski Machado, Pedro H. Doleski, Evelyne da Silva Brum, Francieli Guedes Pintos, Ana Martiele Engelmann, Sara Marchesan Oliveira, Caren Tatiane de David Antoniazzi, Gabriela Trevisan, Cinthia Melazzo de Andrade, Diulle Spat Peres, Daniela B.R. Leal, Liliane de Freitas Bauermann, Diéssica Padilha Dalenogare, Sabrina Qader Kudsi, Camila dos Santos Ritter, Adair R.S. Santos, Camille Gaube Guex, Michele Rorato Sagrillo, Jocelene Filippin Cossetin, Roberta Cougo Riéffel |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Arachis Oecd guideline Administration Oral Kidney weight 010501 environmental sciences Pharmacology Biology Toxicology medicine.disease_cause 030226 pharmacology & pharmacy 01 natural sciences Open field 03 medical and health sciences 0302 clinical medicine medicine Extracellular Animals Rats Wistar 0105 earth and related environmental sciences Plant Extracts food and beverages General Medicine Fabaceae Arachis hypogaea Plant Leaves Toxicity Tests Subacute Alcohols Toxicity Solvents Female Oxidative stress |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 115 |
| ISSN: | 1096-0295 |
| Popis: | Arachis hypogaea L. (peanut) leaf is traditionally used for the treatment of insomnia in Asia. However, studies describing the safety and toxicity profile for this plant preparation are limited. Thus, the goal of this study was to investigate the toxicity of peanut leaf hydroalcoholic extract (PLHE) repeated treatment. The extract was administered orally (100, 300 or 1000 mg/kg) in male and female Wistar rats for 28 days (OECD guideline 407). PLHE treatment did not cause mortality or weight variation in the animals. Also, there was no alteration on locomotor activity (open field test), motor coordination (rotarod test), or anxiety behaviour (elevated plus-maze test). Male rats had a reduction in relative liver weight (100 mg/kg) and an increase in total kidney weight (1000 mg/kg), but there was no change in biochemical and haematological parameters after PLHE treatment. Free extracellular double-stranded DNA (dsDNA) levels was also evaluated, but PLHE treatment did not increase this parameter in rat organs. Also, the dose of 1000 mg/kg of PLHE significantly increased the total thiols in the liver of females compared with the control animals. Thus, PLHE did not induce toxicity after repeated exposure for 28 days in rats. |
| Databáze: | OpenAIRE |
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