A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells
| Autor: | Jin Young Huh, Se Ho Park, Jae Bum Kim, Dong Sup Lee, Sung Hee Choi, Jong In Kim, In Jae Hwang, Rho Hyun Seong, Cheol Soo Choi, Yun Sok Lee, Assim A. Alfadda, Sung Kyu Lee, Yoon Jeong Park, Jee Hyung Sohn, Su Sung Kim |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Cell type Adipose tissue macrophages Population Mice Obese Adipose tissue Inflammation Mice Immune system 3T3-L1 Cells Internal medicine Adipocytes medicine Animals Humans Cytotoxic T cell Obesity education Molecular Biology Mice Knockout Antigen Presentation education.field_of_study biology Articles Cell Biology Lipids Mice Inbred C57BL PPAR gamma Endocrinology Adipose Tissue CD1D Chronic Disease Immunology biology.protein Natural Killer T-Cells Antigens CD1d medicine.symptom |
| Zdroj: | Molecular and Cellular Biology. 33:328-339 |
| ISSN: | 1098-5549 |
| DOI: | 10.1128/mcb.00552-12 |
| Popis: | Systemic low-grade chronic inflammation has been intensively investigated in obese subjects. Recently, various immune cell types, such as macrophages, granulocytes, helper T cells, cytotoxic T cells, and B cells, have been implicated in the pathogenesis of adipose tissue inflammation. However, the roles of invariant natural killer T cells (iNKT cells) and the regulation of iNKT cell activity in adipose tissue are not thoroughly understood. Here, we demonstrated that iNKT cells were decreased in number in the adipose tissue of obese subjects. Interestingly, CD1d, a molecule involved in lipid antigen presentation to iNKT cells, was highly expressed in adipocytes, and CD1d-expressing adipocytes stimulated iNKT cell activity through physical interaction. iNKT cell population and CD1d expression were reduced in the adipose tissue of obese mice and humans compared to those of lean subjects. Moreover, iNKT cell-deficient Jα18 knockout mice became more obese and exhibited increased adipose tissue inflammation at the early stage of obesity. These data suggest that adipocytes regulate iNKT cell activity via CD1d and that the interaction between adipocytes and iNKT cells may modulate adipose tissue inflammation in obesity. |
| Databáze: | OpenAIRE |
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