Development of Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome after Conversion from Plasmacytoma of Bone to Multiple Myeloma

Autor:	Keiko Hatano, Kenta Orimo, Mizuki Ogura, Shingo Okabe, Tadao Ishida, Akatsuki Kubota, Jun Shimizu, Hideji Hashida
Rok vydání:	2023
Předmět:	Internal Medicine General Medicine
Zdroj:	Internal Medicine. 62:475-479
ISSN:	1349-7235 0918-2918
DOI:	10.2169/internalmedicine.9101-21
Popis:	A 36-year-old man developed polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome after conversion from solitary plasmacytoma of bone to multiple myeloma. Twenty-four days following the neurological onset, he lost his independent walking ability. The level of serum vascular endothelial growth factor (VEGF) at diagnosis was 5,250 pg/mL. Three months after initiating treatment, he regained his independent walking ability in line with a reduction in the elevated serum VEGF level. Due to their genomic instability gained during conversion, myeloma cells may overproduce humoral factors and cytokines, possibly contributing to the development of neuropathy as well as the production of VEGF.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94c3906fe04aa1c4f567faada5c9417 https://doi.org/10.2169/internalmedicine.9101-21 Zobrazit plný text záznamu