Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice
| Autor: | Xiaoyun He, Fei Liang, Wentao Xu, Junyu Liu, Chuanhai Zhang, Wenya Xie, Haoyu Li, Kunlun Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Physiology Adipose tissue White adipose tissue Biochemistry Fats chemistry.chemical_compound 0302 clinical medicine Glucose Metabolism Animal Cells Adipocyte Brown adipose tissue Medicine and Health Sciences Adipocytes Medicine Routes of Administration Connective Tissue Cells Glucose tolerance test Multidisciplinary biology medicine.diagnostic_test Animal Models Lipids Blood Sugar Body Fluids Blood medicine.anatomical_structure Physiological Parameters Experimental Organism Systems Adipose Tissue Connective Tissue 030220 oncology & carcinogenesis Brown Adipose Tissue Carbohydrate Metabolism Anatomy Cellular Types hormones hormone substitutes and hormone antagonists Research Article medicine.medical_specialty Science Mouse Models Carbohydrate metabolism Research and Analysis Methods 03 medical and health sciences Model Organisms Internal medicine Obesity Pharmacology business.industry Body Weight Biology and Life Sciences Cell Biology Biological Tissue Metabolism 030104 developmental biology Endocrinology Subcutaneous Injections chemistry Animal Studies biology.protein business Thermogenesis Follistatin |
| Zdroj: | PLoS ONE, Vol 14, Iss 7, p e0220310 (2019) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | With rapid economic development, the prevalence of obesity has increased remarkably worldwide. Obesity can induce a variety of metabolic diseases, such as atherosclerosis, diabetes, hypertension and coronary heart disease, which significantly endanger the health and welfare of individuals. Brown and beige fat tissues play an important role in thermogenesis in mammals. Recent studies have shown that follistatin (FST) can potentially induce the browning of white adipose tissue (WAT). In this study, high-fat diet-induced obese mice were injected with follistatin for one week to explore the effects of follistatin on browning and metabolism and to determine the mechanism. The results showed that follistatin suppressed obesity caused by a high-fat diet and increased insulin sensitivity, energy expenditure, and subcutaneous fat browning. The beneficial effects remained even after a period of withdrawal. Follistatin promoted secretion of irisin from subcutaneous fat via the AMPK-PGC1α-irisin signal pathway, which induces browning of WAT, and activated the insulin pathway in beige fat thereby promoting metabolism. |
| Databáze: | OpenAIRE |
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