Dietary plant stanol esters reduce VLDL cholesterol secretion and bile saturation in apolipoprotein E*3-Leiden transgenic mice
| Autor: | Hans van der Boom, Oscar L. Volger, Gerard Hornstra, Elly de Wit, Jogchum Plat, Louis M. Havekes, Wim van Duyvenvoorde, Hans M.G. Princen, Ronald P. Mensink |
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| Přispěvatelé: | Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Very low-density lipoprotein Diet therapy Lipoproteins Cholesterol VLDL Apolipoprotein E3 Mice Transgenic Biology Lipoproteins VLDL chemistry.chemical_compound Mice Apolipoproteins E Internal medicine medicine Animals Bile Hypolipidemic Agents Cholesterol Reverse cholesterol transport Sitosterols Sterol Diet Mice Inbred C57BL Endocrinology chemistry Plant stanol ester Liver Intestinal cholesterol absorption Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine |
| Zdroj: | Arteriosclerosis Thrombosis and Vascular Biology, 21, 1046-1052. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 1079-5642 |
| DOI: | 10.1161/01.atv.21.6.1046 |
| Popis: | Arterioscler Thromb Vasc Biol 2001 Jun;21(6):1046-52 Related Articles, Books, LinkOut Dietary plant stanol esters reduce VLDL cholesterol secretion and bile saturation in apolipoprotein E*3-Leiden transgenic mice.Volger OL, van der Boom H, de Wit EC, van Duyvenvoorde W, Hornstra G, Plat J, Havekes LM, Mensink RP, Princen HM.TNO Prevention and Health, Leiden, the Netherlands.Dietary plant stanols lower serum cholesterol levels in humans and in hyperlipidemic rodents, mainly by inhibition of the intestinal cholesterol absorption. We used female apolipoprotein E*3-Leiden transgenic mice to investigate the consequences of this effect on serum lipid levels and hepatic lipid metabolism. Five groups of 6 or 7 mice received for 9 weeks a diet containing 0.25% cholesterol and 0.0%, 0.25%, 0.5%, 0.75%, or 1.0% (wt/wt) plant stanols (sitostanol 88% [wt/wt], campestanol 10% [wt/wt]) esterified to fatty acids. Compared with the control diet, plant stanol ester treatment dose-dependently reduced serum cholesterol levels by 10% to 33% (P |
| Databáze: | OpenAIRE |
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