| Popis: |
To compare cryopreserved sutureless amniotic membranes (C-SAM) and dehydrated sutureless amniotic membranes (D-SAM) outpatient treatment outcomes for persistent epithelial defects (PED), analyze risk factors for treatment failure, and identify adverse events.Retrospective interventional comparative clinical study METHODS: This study was a multicenter retrospective interventional cohort from two tertiary corneal referral practices from 2016 to 2020. The inclusion criteria: (1) PEDs treated (2) outpatient with (3) either C-SAM or D-SAM. PEDs were defined as epithelial defects present for ≥7 days after failing prior conservative therapy. The primary outcome measure was resolution or improvement of a PED. The secondary outcomes included analysis of treatment failures and identification of adverse events. A total of 220 PEDs from 204 eyes (197 patients) treated with either C-SAM or D-SAM met the inclusion criteria.100 PEDs (45.5%) resolved following single amniotic membrane administration, 46.5% (59/127) in the C-SAM group and 44.1% (41/93) in the D-SAM group (p = 0.727). 49 PEDs neither improved or resolved without significant difference between C-SAM (21.3%) and D-SAM groups (23.7%, p=0.673). There was no statistically significant difference for PED resolution, PED improvement, PEDs that did not resolve/improve, or those requiring surgery between the two groups for initial SAM.C-SAM and D-SAM were both effective for treating PEDs with comparable outcomes for resolution, improvement, and need for additional surgical intervention. Specific differences in adverse events may help dictate clinical use. Inflammatory disease was a risk factor for non-resolution of all PEDs. |
Full Text from ScienceDirect