Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone
| Autor: | Søren Overgaard, M. Vinther Juhl, Susan Snoek Henriksen, Naseem Theilgaard, Ming Ding |
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| Rok vydání: | 2010 |
| Předmět: |
Scaffold
Ceramics Materials science Long bone Biomedical Engineering Biophysics Bioengineering engineering.material Bone and Bones Biomaterials chemistry.chemical_compound Biopolymers Hyaluronic acid Materials Testing medicine Humans Computer Simulation Ceramic Composite material Biomaterial Lactic acid Transplantation medicine.anatomical_structure chemistry visual_art Bone Substitutes visual_art.visual_art_medium engineering Biopolymer Stress Mechanical Biomedical engineering |
| Zdroj: | Henriksen, S S, Ding, M, Vinther Juhl, M, Theilgaard, N & Overgaard, S 2011, ' Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone ', Journal of Materials Science: Materials in Medicine, vol. 22, no. 5, pp. 1111-1118 . https://doi.org/10.1007/s10856-011-4290-y |
| ISSN: | 1573-4838 |
| DOI: | 10.1007/s10856-011-4290-y |
| Popis: | 2011 May;22(5):1111-8. Epub 2011 Mar 24 Eight groups of calcium-phosphate scaffolds for bone implantation were prepared of which seven were reinforced with biopolymers, poly lactic acid (PLA) or hyaluronic acid in different concentrations in order to increase the mechanical strength, without significantly impairing the microarchitecture. Controls were un-reinforced calcium-phosphate scaffolds. Microarchitectural properties were quantified using micro-CT scanning. Mechanical properties were evaluated by destructive compression testing. Results showed that adding 10 or 15% PLA to the scaffold significantly increased the mechanical strength. The increase in mechanical strength was seen as a result of increased scaffold thickness and changes to plate-like structure. However, the porosity was significantly lowered as a consequence of adding 15% PLA, whereas adding 10% PLA had no significant effect on porosity. Hyaluronic acid had no significant effect on mechanical strength. The novel composite scaffold is comparable to that of human bone which may be suitable for transplantation in specific weight-bearing situations, such as long bone repair. |
| Databáze: | OpenAIRE |
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