Novel Insight of Histamine and Its Receptor Ligands in Glaucoma and Retina Neuroprotection
| Autor: | Cecilia Lanzi, Laura Lucarini, Emanuela Masini, Silvia Sgambellone |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Intraocular pressure
medicine.medical_specialty genetic structures Glaucoma Review Biochemistry Neuroprotection Microbiology intraocular pressure (IOP) chemistry.chemical_compound Cataracts histamine H3R antagonists Ophthalmology Medicine Animals Humans Receptors Histamine H3 Molecular Biology Retina business.industry Retinal medicine.disease histamine eye diseases QR1-502 Disease Models Animal medicine.anatomical_structure chemistry sense organs Histamine H3 receptor business Histamine Histamine H3 Antagonists baro-protection |
| Zdroj: | Biomolecules, Vol 11, Iss 1186, p 1186 (2021) Biomolecules |
| Popis: | Glaucoma is a multifactorial neuropathy characterized by increased intraocular pressure (IOP), and it is the second leading cause of blindness worldwide after cataracts. Glaucoma combines a group of optic neuropathies characterized by the progressive degeneration of retinal ganglionic cells (RGCs). Increased IOP and short-term IOP fluctuation are two of the most critical risk factors in glaucoma progression. Histamine is a well-characterized neuromodulator that follows a circadian rhythm, regulates IOP and modulates retinal circuits and vision. This review summarizes findings from animal models on the role of histamine and its receptors in the eye, focusing on the effects of histamine H3 receptor antagonists for the future treatment of glaucomatous patients. |
| Databáze: | OpenAIRE |
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