IL-1beta, TNFalpha and IL-6 induction in the rat brain after partial-body irradiation: role of vagal afferents
| Autor: | M. Galonnier, D. Clarençon, Patrick Gourmelon, Christine Linard, A. van Uye, C. Marquette, J. Mathieu |
|---|---|
| Přispěvatelé: | Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Centre de Recherches du Service de Santé des Armées (CRSSA), Service de Santé des Armées, Département de Protection et de santé de l'Homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Section Autonome de Radiobiologie Appliquée à la Médecine (IRSN/DPHD/SARAM) |
| Rok vydání: | 2003 |
| Předmět: |
Male
MESH: Hippocampus [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Hippocampus Vagotomy 0302 clinical medicine Thalamus MESH: Vagus Nerve Neural Pathways MESH: Animals MESH: Thalamus Cerebral Cortex MESH: Cytokines Radiological and Ultrasound Technology biology Brain Vagus Nerve Anatomy medicine.anatomical_structure Hypothalamus 030220 oncology & carcinogenesis Cytokines Encephalitis Tumor necrosis factor alpha MESH: Whole-Body Irradiation Whole-Body Irradiation medicine.medical_specialty MESH: Rats Neuroimmunomodulation Central nervous system 03 medical and health sciences MESH: Brain Internal medicine medicine Animals Radiology Nuclear Medicine and imaging Irradiation MESH: Vagotomy Interleukin 6 business.industry Interleukin-6 Tumor Necrosis Factor-alpha MESH: Neural Pathways MESH: Interleukin-1 MESH: Gamma Rays MESH: Hypothalamus MESH: Interleukin-6 MESH: Male MESH: Cerebral Cortex Cortex (botany) Rats Endocrinology nervous system MESH: Neuroimmunomodulation Gamma Rays MESH: Tumor Necrosis Factor-alpha biology.protein MESH: Encephalitis business 030217 neurology & neurosurgery Interleukin-1 |
| Zdroj: | International Journal of Radiation Biology International Journal of Radiation Biology, Informa Healthcare, 2003, 79 (10), pp.777-85. ⟨10.1080/09553000310001610998⟩ International Journal of Radiation Biology, 2003, 79 (10), pp.777-85. ⟨10.1080/09553000310001610998⟩ |
| ISSN: | 0955-3002 1362-3095 |
| DOI: | 10.1080/09553000310001610998⟩ |
| Popis: | International audience; PURPOSE: To evaluate the central nervous system neuroimmune and inflammatory responses during the prodromal phase of the acute irradiation syndrome in rat brains after partial-body exposure (head-protected) and to investigate the potential neural signalling pathways from the irradiated periphery to the non-irradiated brain. MATERIAL AND METHODS: The study included four groups of rats: one irradiated group and one sham irradiated group, each containing non-vagotomized and vagotomized rats. In vagotomized rat groups, the subdiaphragmatic vagal section surgery was carried out 45 days before the irradiation exposure. The rats were partial-body irradiated with the head shielded with (60)Co gamma-rays to a dose of 15 Gy. They were sacrificed 6 h after the end of exposure. The hypothalamus, hippocampus, thalamus and cortex were then collected, and the concentrations of IL-1beta, TNFalpha and IL-6 in each were measured by ELISA assays. RESULTS: Six hours after irradiation, IL-1beta levels had increased in the hypothalamus, thalamus and hippocampus, and TNFalpha and IL-6 levels had increased significantly in the hypothalamus. Vagotomy before irradiation prevented these responses. CONCLUSIONS: It was concluded that the hypothalamus, hippocampus, thalamus and cortex react rapidly to peripheral irradiation by releasing pro-inflammatory mediators. The results also show that the vagus nerve is one of the major ascending pathways for rapid signalling to the brain with respect to partial body irradiation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|