Saccharomyces boulardii CNCM I-745 Improves Intestinal Enzyme Function
| Autor: | Yvan Vandenplas, Margret I Moré |
|---|---|
| Přispěvatelé: | Clinical sciences, Growth and Development, Pediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
trophic effects
medicine.medical_treatment polyamines gastroenterology Review Biology yeast Probiotic law.invention Microbiology 03 medical and health sciences Enzyme activator 0302 clinical medicine law medicine PI3K/AKT/mTOR pathway Saccharomyces boulardii CNCM I-745 chemistry.chemical_classification Prebiotic biology.organism_classification medicine.disease Yeast brush border membrane enzymes diarrhoea Enzyme chemistry 030220 oncology & carcinogenesis digestive enzymes prebiotic Dysbiosis 030211 gastroenterology & hepatology Saccharomyces boulardii |
| Zdroj: | Clinical Medicine Insights. Gastroenterology |
| Popis: | Several properties of the probiotic medicinal yeast Saccharomyces boulardii CNCM I-745 contribute to its efficacy to prevent or treat diarrhoea. Besides immunologic effects, pathogen-binding and anti-toxin effects, as well as positive effects on the microbiota, S boulardii CNCM I-745 also has pronounced effects on digestive enzymes of the brush border membrane, known as trophic effects. The latter are the focus of this review. Literature has been reviewed after searching Medline and PMC databases. All relevant non-clinical and clinical studies are summarized. S. boulardii CNCM I-745 synthesizes and secretes polyamines, which have a role in cell proliferation and differentiation. The administration of polyamines or S. boulardii CNCM I-745 enhances the expression of intestinal digestive enzymes as well as nutrient uptake transporters. The signalling mechanisms leading to enzyme activation are not fully understood. However, polyamines have direct nucleic acid–binding capacity with regulatory impact. S. boulardii CNCM I-745 induces signalling via the mitogen-activated protein kinase pathway. In addition, effects on the phosphatidylinositol-3 kinase (PI3K) pathway have been reported. As an additional direct effect, S. boulardii CNCM I-745 secretes certain enzymes, which enhance nutrient acquisition for the yeast and the host. The increased availability of digestive enzymes seems to be one of the mechanisms by which S. boulardii CNCM I-745 counteracts diarrhoea; however, also people with certain enzyme deficiencies may profit from its administration. More studies are needed to fully understand the mechanisms of trophic activation by the probiotic yeast. |
| Databáze: | OpenAIRE |
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