Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations
| Autor: | Fábio Coelho Amendoeira, Laís Bastos da Fonseca, Abdul Basit, Alessandra Lifsitch Viçosa, Janine Boniatti, Alvaro Goyanes, Maria-Inês Ré, Patricija Januskaite, Catherine Tuleu |
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| Přispěvatelé: | Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), University College of London [London] (UCL), Universidade de Santiago de Compostela [Spain] (USC ) |
| Rok vydání: | 2021 |
| Předmět: |
personalized therapeutics
3d printed Materials science Pellets Pharmaceutical Science 3D printing 02 engineering and technology 030226 pharmacology & pharmacy Article translational pharmaceutics 03 medical and health sciences Pharmacy and materia medica 0302 clinical medicine oral drug delivery systems and technologies medicine Taste masking Hot melt business.industry 3D printed drug products Neglected Disease 021001 nanoscience & nanotechnology taste masking 3. Good health RS1-441 Praziquantel M3DIMAKER printer [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology printing pharmaceuticals and medicines Chemical engineering Direct 3D printing pediatric treatments Extrusion 0210 nano-technology business material extrusion additive manufacturing medicine.drug |
| Zdroj: | Pharmaceutics Pharmaceutics, MDPI, 2021, 13 (8), pp.1-19/1114. ⟨10.3390/pharmaceutics13081114⟩ Volume 13 Issue 8 Pharmaceutics, Vol 13, Iss 1114, p 1114 (2021) |
| ISSN: | 1999-4923 |
| Popis: | International audience; For the last 40 years, praziquantel has been the standard treatment for schistosomiasis, a neglected parasitic disease affecting more than 250 million people worldwide. However, there is no suitable paediatric formulation on the market, leading to off-label use and the splitting of commercial tablets for adults. In this study, we use a recently available technology, direct powder extrusion (DPE) three-dimensional printing (3DP), to prepare paediatric Printlets™ (3D printed tablets) of amorphous solid dispersions of praziquantel with Kollidon® VA 64 and surfactants (Span™ 20 or Kolliphor® SLS). Printlets were successfully printed from both pellets and powders obtained from extrudates by hot melt extrusion (HME). In vitro dissolution studies showed a greater than four-fold increase in praziquantel release, due to the formation of amorphous solid dispersions. In vitro palatability data indicated that the printlets were in the range of praziquantel tolerability, highlighting the taste masking capabilities of this technology without the need for additional taste masking excipients. This work has demonstrated the possibility of 3D printing tablets using pellets or powder forms obtained by HME, avoiding the use of filaments in fused deposition modelling 3DP. Moreover, the main formulation hurdles of praziquantel, such as low drug solubility, inadequate taste, and high and variable dose requirements, can be overcome using this technology. |
| Databáze: | OpenAIRE |
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