Application of curcumin and its derivatives in tumor multidrug resistance
| Autor: | Xianhu Feng, Chao Pi, Qingsheng Jiang, Ting Xu, Yuanyuan Wang, Pu Guo, Yi Hou, Yumeng Wei, Ling Zhao, Yingmeng He |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Curcumin
medicine.medical_treatment 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neoplasms Antineoplastic Combined Chemotherapy Protocols medicine Animals Humans Reversal effect Pharmacology Antitumor activity 0303 health sciences Chemotherapy Signal Pathways Tumor chemotherapy business.industry 030302 biochemistry & molecular biology Antineoplastic Agents Phytogenic Combined Modality Therapy Drug Resistance Multiple Multiple drug resistance chemistry Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research business Phytotherapy Signal Transduction |
| Zdroj: | Phytotherapy research : PTRREFERENCES. 34(10) |
| ISSN: | 1099-1573 |
| Popis: | Malignant tumor endangers seriously the health of all mankind. Multidrug resistance (MDR) is one of the main causes of clinical tumor chemotherapy failure. Curcumin (CUR) has not only antitumor activity but also reversing tumor MDR effect. CUR reverses tumor MDR via regulating related signal pathways or corresponding expressed proteins or gene. When combined with chemotherapeutic agents, CUR can be a chemotherapeutic sensitive agent to enhance chemotherapy efficacy and weaken tumor MDR. On the other hand, to improve the MDR reversal effect of CUR, its derivatives have been extensively studied. Therefore, this article mainly focuses on reviewing the application of CUR and its derivatives in MDR and its mechanism of reversing MDR. |
| Databáze: | OpenAIRE |
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