Recent Advances in pH- or/and Photo-Responsive Nanovehicles
| Autor: | Yu Seok Youn, Kioh Kang, Dayoon Lee, Yuseon Shin, Kyung-Taek Oh, Eun Seong Lee, Patihul Husni, Sehwa Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Tumor targeting
photodynamic Computer science protonation Pharmaceutical Science Nanotechnology 02 engineering and technology Review 010402 general chemistry chemotherapy 01 natural sciences stimuli photothermal Pharmacy and materia medica Controlled delivery acid-labile bond nanovehicles pH Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences RS1-441 Drug delivery 0210 nano-technology light Photo responsive |
| Zdroj: | Pharmaceutics, Vol 13, Iss 725, p 725 (2021) Pharmaceutics |
| ISSN: | 1999-4923 |
| Popis: | The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger. |
| Databáze: | OpenAIRE |
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