Route of intrabacterial nanotransportation system for CagA in Helicobacter pylori
| Autor: | Takashi Nakano, Kouichi Sano, Sonoko Ishihara, Yukimasa Ooi, Noritaka Iwai, Hong Wu |
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| Rok vydání: | 2015 |
| Předmět: |
Cytoplasm
Immunoelectron microscopy Biological Transport Active digestive system MreB Pathology and Forensic Medicine Microbiology Bacterial Proteins CagA Microscopy Immunoelectron Molecular Biology Antigens Bacterial Helicobacter pylori biology Chemistry Thiourea General Medicine bacterial infections and mycoses biology.organism_classification Urease digestive system diseases Protein Transport bacteria Bacteria |
| Zdroj: | Medical Molecular Morphology. 48:191-203 |
| ISSN: | 1860-1499 1860-1480 |
| Popis: | Helicobacter pylori (H. pylori) possesses an intrabacterial nanotransportation system (ibNoTS) for transporting CagA and urease within the bacterial cytoplasm; this system is controlled by the extrabacterial environment. The transportation routes of the system have not yet been studied in detail. In this study, we demonstrated by immunoelectron microscopy that CagA localizes closely with the MreB filament in the bacterium, and MreB polymerization inhibitor A22 obstructs ibNoTS for CagA. These findings indicate that the route of ibNoTS for CagA is closely associated with the MreB filament. Because these phenomena were not observed in ibNoTS for urease, the route of ibNoTS for CagA is different from that of ibNoTS for urease as previously suggested. We propose that the route of ibNoTS for CagA is associated with the MreB filament in H. pylori. |
| Databáze: | OpenAIRE |
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