Development and Evaluation of Matrices Composed of β-cyclodextrin and Biodegradable Polyesters in the Controlled Delivery of Pindolol
| Autor: | Agata Drobniewska, Marcin Sobczak, Filip Charuk, Ewa Oledzka, Łukasz Szeleszczuk, Anna Zgadzaj, Agnieszka Lis-Cieplak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:RS1-441
Pharmaceutical Science 02 engineering and technology polyesters 010402 general chemistry 01 natural sciences Article lcsh:Pharmacy and materia medica drug delivery systems Magic angle spinning functionalization of polymers chemistry.chemical_classification Cyclodextrin polymeric conjugate Polymer 021001 nanoscience & nanotechnology Biodegradable polymer Combinatorial chemistry 0104 chemical sciences Polyester Polymerization chemistry β-cyclodextrin Proton NMR natural initiator 0210 nano-technology Conjugate pindolol |
| Zdroj: | Pharmaceutics Volume 12 Issue 6 Pharmaceutics, Vol 12, Iss 500, p 500 (2020) |
| ISSN: | 1999-4923 |
| Popis: | Polymer-drug conjugates are currently being more widely investigated for the treatment of hypertension. In view of the above, in the first stage of our work, we used nontoxic &beta cyclodextrin (&beta CD) as effective, simple, inexpensive, and safe for the human body initiator for the synthesis of biocompatible and biodegradable functionalized polymers suitable for the medical and pharmaceutical applications. The obtained polymeric products were synthesized through a ring-opening polymerization (ROP) of &epsilon caprolactone (CL), d,l-, and l,l- lactide (LA and LLA). The chemical structures of synthesized materials were elucidated based on 1H NMR and solid-state carbon-13 cross-polarization/magic angle spinning nuclear magnetic resonance (13C CP/MAS NMR) analysis, while the incorporation of &beta CD molecule into the polymer chain was confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Furthermore, molecular modeling has been applied to investigate the intrachain rigidities and chain architectures for several representative structures. The obtained and thoroughly characterized branched matrices were then used to generate the first &beta cyclodextrin/biodegradable polymer/&beta blocker conjugate through the successful conjugation of pindolol. The conjugates were fabricated by carbodiimide-mediated coupling reaction. The branched biodegradable materials released the drug in vitro in a sustained manner and without &ldquo burst release&rdquo and thus have the ability to treat different heart diseases. |
| Databáze: | OpenAIRE |
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