Long‐term Follow‐up After Radiation Therapy for Laryngeal Amyloidosis
| Autor: | Joshua S. Schindler, Caitlin Bertelsen, Paul W. Flint, Keith Chadwick, John M. Holland |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Larynx medicine.medical_specialty Long term follow up medicine.medical_treatment Disease Laryngeal Diseases 03 medical and health sciences 0302 clinical medicine Laryngeal amyloidosis Recurrence Humans Medicine 030223 otorhinolaryngology Aged Retrospective Studies Laryngoscopy business.industry Amyloidosis Retrospective cohort study Middle Aged medicine.disease Surgery Radiation therapy Treatment Outcome medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant business Follow-Up Studies Rare disease |
| Zdroj: | The Laryngoscope. 131:1810-1815 |
| ISSN: | 1531-4995 0023-852X |
| Popis: | OBJECTIVES Laryngeal amyloidosis (LA) is a rare disease characterized by extracellular protein deposition within the larynx. Treatment is difficult due to the frequently submucosal and multifocal nature of disease. The mainstay of treatment is surgical resection; however, recurrence rates are high. Recently, use of radiotherapy (RT), either alone or postoperatively, for LA has been adapted from the management of extramedullary plasmacytoma and has been shown to provide local disease control. Here, we describe the experience with adjuvant RT for LA at our center. STUDY DESIGN Retrospective case series. METHODS Retrospective study of patients with amyloidosis of the larynx, with or without other disease sites, seen at a tertiary academic center between 2011 and 2019. Outcomes included disease characteristics, recurrence rates, treatment modalities, and pre- and posttreatment voice handicap index (VHI)-10. RESULTS Ten patients met eligibility criteria. Mean follow-up time for all patients was 62.0 ± 41.0 months; mean follow-up time after last treatment was 51 ± 55 months. All but one patient underwent surgical resection of disease. Seven patients underwent subsequent RT. Of these seven, six underwent RT at our institution; five received a dose of 45 Gray (Gy); and one received a dose of 20 Gy. All seven completed RT without toxicity-related interruption. Patients undergoing RT underwent 2.1 ± 1.3 surgical procedures prior to RT; no patients required surgery after RT. Mean pretreatment VHI-10 was 22.9 ± 8.1; mean posttreatment VHI-10 was 12.9 ± 13.3. CONCLUSION RT after surgery for LA can provide good local control without unacceptable toxicity and may decrease the need for further surgery. LEVEL OF EVIDENCE 4 Laryngoscope, 131:1810-1815, 2021. |
| Databáze: | OpenAIRE |
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