Sodium Fluoride-18 and Radium-223 Dichloride Uptake Colocalize in Osteoblastic Mouse Xenograft Tumors
| Autor: | Karen Wong, Elaine M. Jagoda, Jurgen Seidel, Amy K. LeBlanc, Ling Ren, Michael V. Green, Jennifer L Matta, Peter L. Choyke, Elijah F. Edmondson, Shan Huang, Anita T. Ton, Tim Phelps, Jyoti Roy, Donna Butcher, Kwamena E. Baidoo, Stephen Adler |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Radium-223 Cancer Research Sodium chemistry.chemical_element Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mouse xenograft Cell Line Tumor Original Research Articles Sodium fluoride medicine Animals Humans Radiology Nuclear Medicine and imaging Positron emission Radium-223 Dichloride Pharmacology Osteoblasts Colocalization General Medicine Xenograft Model Antitumor Assays Disease Models Animal 030104 developmental biology Oncology chemistry Bone lesion 030220 oncology & carcinogenesis Cancer research Sodium Fluoride Female Radium medicine.drug |
| Zdroj: | Cancer Biother Radiopharm |
| ISSN: | 1557-8852 1084-9785 |
| DOI: | 10.1089/cbr.2020.4068 |
| Popis: | Background: Patients with osteoblastic bone metastases are candidates for radium-223 ((223)RaCl(2)) therapy and may undergo sodium fluoride-18 ((18)F-NaF) positron emission tomography-computed tomography imaging to identify bone lesions. (18)F-NaF has been shown to predict (223)RaCl(2) uptake, but intratumor distributions of these two agents remain unclear. In this study, the authors evaluate the spatial distribution and relative uptakes of (18)F-NaF and (223)RaCl(2) in Hu09-H3 human osteosarcoma mouse xenograft tumors at macroscopic and microscopic levels to better quantify their correlation. Materials and Methods: (18)F-NaF and (223)RaCl(2) were co-injected into Hu09-H3 xenograft tumor severe combined immunodeficient mice. Tumor content was determined from in vivo biodistributions and visualized by PET, single photon emission computed tomography, and CT imaging. Intratumor distributions were visualized by quantitative autoradiography of tumor tissue sections and compared to histology of the same or adjacent sections. Results: (18)F and (223)Ra accumulated in proportional amounts in whole Hu09-H3 tumors (r(2) = 0.82) and in microcalcified regions within these tumors (r(2) = 0.87). Intratumor distributions of (18)F and (223)Ra were spatially congruent in these microcalcified regions. Conclusions: (18)F-NaF and (223)RaCl(2) uptake are strongly correlated in heterogeneously distributed microcalcified regions of Hu09-H3 xenograft tumors, and thus, tumor accumulation of (18)F is predictive of (223)Ra accumulation. Hu09-H3 xenograft tumors appear to possess certain histopathological features found in patients with metastatic bone disease and may be useful in clarifying the relationship between administered (223)Ra dose and therapeutic effect. |
| Databáze: | OpenAIRE |
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