Decreased Basal Tear Turnover in Patients With Untreated Primary Open-Angle Glaucoma
| Autor: | Rob J. W. de Keizer, Jaap A. Van Best, C. C. Sterk, E. V. M. J. Kuppens |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraocular pressure genetic structures Open angle glaucoma Eye disease Ocular hypertension Glaucoma Fluorophotometry Basal (phylogenetics) Ophthalmology medicine Humans In patient Intraocular Pressure Aged Aged 80 and over business.industry Middle Aged medicine.disease eye diseases Tears Dry Eye Syndromes Female Ocular Hypertension sense organs business Glaucoma Open-Angle |
| Zdroj: | American Journal of Ophthalmology. 120:41-46 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/s0002-9394(14)73757-2 |
| Popis: | Purpose To detect whether untreated primary open-angle glaucoma or ocular hypertension is associated with an impaired basal tear turnover. Methods Basal tear turnover was determined by fluorophotometry in 18 patients with newly detected, untreated primary open-angle glaucoma and 29 patients with untreated ocular hypertension. The results were compared with those of 27 age-matched control subjects. Results The basal tear turnover in glaucoma patients (mean ± S.D., 11.4 ± 3.1%/min) was 22% lower than in patients with ocular hypertension (14.7 ± 3.0%/min; P=.0007) and 27% lower than in control subjects (15.7 ± 5.3%/min; P=.001). Tear turnover of patients with ocular hypertension did not differ significantly from that of control subjects (P = .4). The basal tear turnover values were found to decrease with increasing vertical or horizontal cup/disk ratios (P = .004 and P=.008, respectively). Conclusions Primary open-angle glaucoma, but not ocular hypertension, was found to be associated with an impaired basal tear turnover. Dry eye complaints may originate from decreased basal tear turnover as a result of glaucoma drug therapy as well as from primary open-angle glaucoma itself. |
| Databáze: | OpenAIRE |
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