Identifying components of the NF-kappaB pathway in the beneficial Euprymna scolopes-Vibrio fischeri light organ symbiosis
| Autor: | M. Bento Soares, Todd E. Scheetz, Thomas L. Casavant, Mila Kojadinovic, Michael S. Goodson, Margaret J. McFall-Ngai, Joshua V. Troll |
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| Rok vydání: | 2005 |
| Předmět: |
DNA
Complementary Euprymna scolopes Light Transcription Genetic Molecular Sequence Data Applied Microbiology and Biotechnology Phosphorylation cascade Microbiology chemistry.chemical_compound Light organ Species Specificity Invertebrate Microbiology Animals Humans Aliivibrio fischeri Amino Acid Sequence Symbiosis Transcription factor Expressed Sequence Tags Innate immune system Ecology biology fungi Decapodiformes NF-kappa B Animal Structures NF-κB biology.organism_classification Cell biology chemistry Gene Expression Regulation Organ Specificity Signal transduction Food Science Biotechnology Signal Transduction |
| Zdroj: | Applied and environmental microbiology. 71(11) |
| ISSN: | 0099-2240 |
| Popis: | The Toll/NF-κB pathway is a common, evolutionarily conserved innate immune pathway that modulates the responses of animal cells to microbe-associated molecular patterns (MAMPs). Because MAMPs have been implicated as critical elements in the signaling of symbiont-induced development, an expressed sequence tag library from the juvenile light organ of Euprymna scolopes was used to identify members of the Toll/NF-κB pathway. Full-length transcripts were identified by using 5′ and 3′ RACE PCR. Seven transcripts critical for MAMP-induced triggering of the Toll/NF-κB phosphorylation cascade have been identified, including receptors, signal transducers, and a transcription factor. Further investigations should elucidate the role of the Toll/NF-κB pathway in the initiation of the beneficial symbiosis between E. scolopes and Vibrio fischeri . |
| Databáze: | OpenAIRE |
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